The Contribution of Genotype to Heterotopic Ossification after Orthopaedic Trauma

Abstract

We build on our earlier findings of three potential contributing genetic factors (ADRB2, TLR4, CFH)in the development of heterotopic ossification (HO). Demographic and environmental data for 1313 patients were compiled in addition to radiographic findings of HO in the same cohort. Statistical analyses were performed to determine associations between ISS, head AIS, ICU days, days on ventilator support, race and gender on the development of HO. In addition, we have begun extraction on another 1161 patient specimens to add genetic data to the 2426 specimens already extracted in our repository. Along with the 36 SNPs we planned to investigate in our original proposal, we will add an additional 60 SNPs to include more pathways recently identified in the literature and that are associated with our initial findings.

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Document Details

Document Type
Technical Report
Publication Date
May 01, 2010
Accession Number
ADA613874

Entities

People

  • Erika J. Mitchell

Organizations

  • Vanderbilt University Medical Center

Tags

DTIC Thesaurus Topics

  • Biomedical Research
  • Bone Diseases
  • Congenital Hereditary And Neonatal Diseases And Abnormalities
  • Genes
  • Genetic Phenomena
  • Genetic Structures
  • Genetics
  • Genotypes
  • Heterotopic Ossification
  • Osteogenesis
  • Osteoporosis
  • Peptide Growth Factors

Readers

  • Aerial Delivery - Logistics and Supply Chain Management.
  • Molecular and genetic basis of cancer.
  • Trauma or Military Medicine

Technology Areas

  • Biotechnology