The Contribution of Genotype to Heterotopic Ossification after Orthopaedic Trauma

Abstract

We build on our earlier findings of three potential contributing genetic factors (ADRB2, TLR4, CFH)in the development of heterotopic ossification (HO). HO development in long bone fractures correlated with all of these variables but was inversely associated with head injury scores. With more recent data we have determined that the ADRB2 minor allele is associated with HO formation in our patient population however, TLR4 and CFH no longer demonstrate significance.

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Document Details

Document Type
Technical Report
Publication Date
May 01, 2011
Accession Number
ADA613875

Entities

People

  • Erika J. Mitchell

Organizations

  • Vanderbilt University Medical Center

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Biomedical Research
  • Bone Fractures
  • Department Of Defense
  • Electronic Mail
  • Genetics
  • Genotypes
  • Governments
  • Head Injuries
  • Heterotopic Ossification
  • Information Operations
  • Instructions
  • National Governments
  • Osteogenesis

Readers

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  • Trauma or Military Medicine
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Technology Areas

  • Biotechnology
  • Biotechnology - Cancer Biotech