Development of Targeted Nanobubbles for Ultrasound Imaging and Ablation of Metastatic Prostate Cancer Lesions

Abstract

We already reported the synthesis of the amphiphilic PEG-b-(PAA)-b-P(HDFMA-co-MMA) copolymers that proved to encapsulate 1%-2% v/v PFP forming nanodroplets. We showed that NDs were able to ablate neighboring RBC as a model cells In this report, we investigated NDs ablation of prostate cells as well as the effects of ultrasound frequency on the pressure required to generate histotripsy cavitation bubbles and the resulting bubble dynamics. Results demonstrated complete fractionation and removal of cancer cells exposed to nanodroplet induced bubbles. These preliminary results support our hypothesis that ND-mediated histotripsy can be used for tumor ablation.

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Document Details

Document Type
Technical Report
Publication Date
Aug 01, 2014
Accession Number
ADA613959

Entities

People

  • Mohamed E. El-sayed

Organizations

  • University of Michigan

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Ablation
  • Blood
  • Cavitation
  • Chemistry
  • Detection
  • Field Programmable Gate Arrays
  • Fractionation
  • Frequency
  • High Speed Cameras
  • Image Processing
  • Light Sources
  • Mechanical Properties
  • Prostate
  • Prostate Cancer
  • Three Dimensional
  • Tissues
  • Ultrasounds

Readers

  • Oncology
  • Pulsed Power and Plasma Physics.
  • Underwater engineering and Marine Technology.

Technology Areas

  • Microelectronics