Opioid Abuse after TBI
Abstract
The goal of this project is to evaluate the hypothesis that traumatic brain injury induces alterations in the brain s reward circuitry which may make an injured brain more susceptible to the rewarding effects of opioids. We are currently conducting experiments to evaluate the hypothesis that TBI causes changes in the analgesic response to opioids following acute and repeated drug administration. We are also testing the hypothesis that moderate TBI increases the susceptibility for opioid abuse as measured by an alteration in the rewarding properties of oxycodone. We have completed the third year of experimentation and thus far have found that TBI induces changes in oxycodone abuse-related behaviors and may induce alteration in the brain reward, particularly expression of the dopamine receptor subtype 2. All studies are on-going.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2014
- Accession Number
- ADA613999
Entities
People
- Candance L. Floyd
- Katherine L. Nicholson
Organizations
- University of Alabama