Identification of Genes and Genetic Variants Associated with Poor Treatment Response in Patients with Prostate Cancer

Abstract

We have created an informative set of high risk lethal prostate cancer pedigrees and recurrent prostate cancer cases. Linkage analysis has identified significant evidence for linkage several chromosomes; these findings will be followed with sequence analysis. We have begun sequence analysis and identified a set of candidate genes in a set of 6 pairs of lethal prostate cancer cases sequenced. We have begun GWAS analysis on our set of deeply phenotypes recurrent cases and have identified some significant findings. Manuscript preparation is underway. Identification of genes predisposing to recurrent/lethal prostate cancer from this study will validate this powerful approach, which can be extended to other high risk prostate cancer pedigrees, and will identify genes and pathways that can be further examined to expand our knowledge of prostate cancer genetics.

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Document Details

Document Type
Technical Report
Publication Date
Dec 01, 2014
Accession Number
ADA614000

Entities

People

  • Craig Teerlink
  • Lisa Cannon-Albright
  • Neeraj Agarwal

Organizations

  • University of Utah

Tags

DTIC Thesaurus Topics

  • Biomedical Research
  • Cancer
  • Chromosomes
  • Databases
  • Department Of Veterans Affairs
  • Diseases And Disorders
  • Genes
  • Genetic Phenomena
  • Genetic Structures
  • Genetics
  • Genome
  • Identification
  • Neoplasms
  • Phenotypes
  • Prostate Cancer
  • Sequence Analysis
  • Sequences

Fields of Study

  • Biology

Readers

  • Molecular and genetic basis of cancer.

Technology Areas

  • Biotechnology