7T Magnetization Transfer and Chemical Exchange Saturation Transfer MRI of Cortical Gray Matter: Can We Detect Neurochemical and Macromolecular Abnormalities?

Abstract

We present the first annual report for this project. We have developed and deployed a quantitative MRI set of MRI scans at 7T in healthy volunteers and have developed an analysis pipeline for the quantification of macromolecular and metabolic indices reflective of demyelination and neurotransmitter/protein accumulation. All quantitative MRI methods deployed in humans were optimized and vetted via phantom work and simulation. We are happy to report initial findings that show excellent image quality and differences between the normal cohort and one MS patient. Additionally, we have developed, in conjunction with Dr. Newhouse, a neurocognition expert, an extensive neuropsychiatric battery for correlation studies in year 2. We have had excellent recruitment and retention and look forward to group comparisons in year 2.

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Document Details

Document Type
Technical Report
Publication Date
Oct 21, 2014
Accession Number
ADA614127

Entities

People

  • Seth A. Smith

Organizations

  • Vanderbilt University

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Acquisition
  • Albumins
  • Brain
  • Cognitive Impairment
  • Data Analysis
  • Equations
  • Frequency
  • Geometry
  • Health Services
  • Heart Rate
  • High Resolution
  • Magnetic Resonance
  • Neuroimaging
  • Reliability
  • Simulations
  • Sound Pressure
  • Three Dimensional

Fields of Study

  • Medicine

Readers

  • Image Processing and Computer Vision.
  • Neuroscience
  • Research Science/Academic Research