Radiation-Induced Vaccination to Breast Cancer

Abstract

The purpose of this study is to combine the TGFbeta neutralizing antibody, Fresolimumab, with Radiation Therapy (RT) to treat metastatic breast cancer. This is based on the rationale that RT can be limited to 1 or 2 lesions which in turn serve as antigenic reservoirs that drive abscopal effects. Patients receive either 1mg or 10mg of the anti-TGFbeta antibody.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2014
Accession Number
ADA614132

Entities

People

  • William H. Mcbride

Organizations

  • University of California, Los Angeles

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Antibodies
  • Blood
  • Breast Cancer
  • Cells
  • Data Sets
  • Immune System
  • Inhibitors
  • Lymphocytes
  • Molecules
  • Neoplasms
  • Peptide Growth Factors
  • Radiation
  • Statistical Analysis
  • Stem Cells
  • Therapy
  • Vaccination

Readers

  • Oncology (Cancer Research).

Technology Areas

  • Biotechnology
  • Biotechnology - Cancer Biotech