Americium-241 Decorporation Model

Abstract

A treatment model for Am-241 internal contamination by DTPA was developed to evaluate efficacy of various treatment regimens. The model estimates Am deposition, absorption, distribution, retention, excretion, and response to DTPA after an inhalation exposure. It estimates the acute red bone marrow and lung doses and whole body effective dose as a function of time. Model results compare favorably with human and animal data. Outputs from the model include Am deposition in the respiratory tract, distribution in tissue compartments over time with and without treatment, excretion rates, and radiation doses to critical organs. Calculations from the model may be used to analyze consequences of exposure to Am-241 and the effect of treatment.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2014
Accession Number
ADA614283

Entities

People

  • Daniela Stricklin
  • Gene E. Mcclellan
  • Jason Rodriguez
  • Kyle K. Millage

Organizations

  • Applied Research Associates (United States)

Tags

DTIC Thesaurus Topics

  • Actinides
  • Alpha Particles
  • Americium
  • Bone Marrow
  • Bones
  • Case Studies
  • Department Of Defense
  • Digestive System Processes
  • Gastrointestinal Tract
  • Medical Personnel
  • Metals
  • Particle Size
  • Radiation
  • Radiation Protection
  • Radioactive Decay
  • Radioactive Materials
  • Transuranium Elements

Readers

  • Computational Modeling and Simulation
  • Nuclear and Radiation Engineering.
  • Toxicology/Environmental Toxicology