Role of Extracellular miR-122 in Breast Cancer Metastasis
Abstract
Reprogrammed glucose metabolism due to increased glycolysis and glucose uptake is a hallmark of cancer. We show that cancer cells can suppress glucose metabolism in endothelial, lung fibroblasts, and brain astrocyte niche cells through secreting exosomal miR-122, a miRNA whose level in the circulation predicts metastasis of breast cancer. MiR-122 suppresses glucose uptake and metabolism primarily through down-regulating the glycolytic enzyme pyruvate kinase M2 (PKM2). Our results demonstrate that cancer cells are capable of influencing how niche cells metabolize glucose through exosome secretion of miR-122 and the consequent down-regulation of glucose metabolic enzymes in niche cells leading to reduced glucose utilization.
Document Details
- Document Type
- Technical Report
- Publication Date
- Feb 01, 2015
- Accession Number
- ADA614409
Entities
People
- Miranda Fong