Activity of Imipenem against Klebsiella pneumoniae Biofilms In Vitro and In Vivo

Abstract

Encapsulated Klebsiella pneumoniae has emerged as one of the most clinically relevant and more frequently encountered opportunistic pathogens in combat wounds as the result of nosocomial infection. In this report, we show that imipenem displayed potent activity against established K. pneumoniae biofilms under both static and flow conditions in vitro. Using a rabbit ear model, we also demonstrated that imipenem was highly effective against preformed K. pneumoniae biofilms in wounds.

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Document Details

Document Type
Technical Report
Publication Date
Feb 01, 2014
Accession Number
ADA614489

Entities

People

  • Akhil K. Seth
  • Johnathan J. Abercrombie
  • Kai Poon Leung
  • Ping Chen
  • Thomas A. Mustoe

Organizations

  • United States Army Institute of Surgical Research

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Anti-Bacterial Agents
  • Anti-Infective Agents
  • Bacteria
  • Burns
  • Chemotherapy
  • Combat Injuries
  • Health Services
  • Infection
  • Liquid Chromatography
  • Microbiology
  • Wound Healing
  • Wound Infections

Fields of Study

  • Biology

Readers

  • Military/Explosive Ordnance Disposal (EOD) Technology
  • Trauma or Military Medicine
  • Virology (or Medical Virology).

Technology Areas

  • Biotechnology