A Comprehensive Tool and Analytical Pathway for Differential Molecular Profiling and Biomarker Discovery

Abstract

Comprehensive and reproducible sample collection techniques were developed concomitantly with the informatics tool and used in multiple, independent studies for the validation and further development of generated software tools and approaches. Data from a dose-response study examining an organ specific environmental toxicant exposure was analyzed using the prototype software tool for discovery of LC/MS based metabolomic biomarkers.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Oct 20, 2014
Accession Number
ADA614501

Entities

People

  • Claude C. Grigsby

Organizations

  • Air Force Research Laboratory

Tags

Communities of Interest

  • Autonomy
  • C4I
  • Energy and Power Technologies
  • Human Systems

DTIC Thesaurus Topics

  • Air Force
  • Alkenes
  • Chemical Synthesis
  • Chemistry
  • Computational Science
  • Data Mining
  • Gene Expression
  • Information Science
  • Ketones
  • Liquid Chromatography
  • Machine Learning
  • Mass Spectrometry
  • Medical Personnel
  • Optical Materials
  • Organic Chemistry
  • Supervised Machine Learning
  • Two Dimensional

Readers

  • Molecular and Cellular Biology
  • Systems Analysis and Design
  • Toxicology/Environmental Toxicology