Hydrogen Sulfide Mitigates Reperfusion Injury in a Porcine Model of Vascularized Composite Autotransplantation

Abstract

Devastating extremity injuries are prevalent but often survivable on the modern battlefield. These complex injuries require advanced methods of reconstruction, involving prolonged ischemic periods and reperfusion injury. Using our group s validated porcine model of gracilis myocutaneous flap transplantation, this study demonstrates that an interim perfusion of hydrogen sulfide (H2S) mitigates the effects of reperfusion injury in the setting of delayed restoration of blood flow.

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Document Details

Document Type
Technical Report
Publication Date
May 01, 2014
Accession Number
ADA614510

Entities

People

  • C. A. Fries
  • Carole Y. Villamaria
  • Jerry R. Spencer
  • Mark Roth
  • Michael R. Davis

Organizations

  • United States Army Institute of Surgical Research

Tags

DTIC Thesaurus Topics

  • Allografts
  • Arteries
  • Blood
  • Body Regions
  • Chemistry
  • Composite Materials
  • Dielectric Gases
  • Electronic Mail
  • Hydrogen
  • Hydrogen Sulfides
  • Laboratory Animals
  • Neoplasms
  • Skeletal Muscle
  • Sulfides
  • Transplants
  • Vascular Diseases
  • Veins

Fields of Study

  • Medicine

Readers

  • Aerospace Engineering
  • Molecular and Cellular Biochemistry
  • Neuroscience

Technology Areas

  • Biotechnology