Fibrinogen Concentrate in Dilutional Coagulopathy: a Dose Study in Pigs

Abstract

Dilutional coagulopathy can be reversed with fibrinogen concentrate. Effects of different fibrinogen dosages on clot function are not defined; high doses my increase the risk of thromboemboembolism. This study investigated the effect of six fibrinogen dosages on coagulation profile and blood loss in coagulopathic pigs. Forty-two pigs underwent a 60% hemodilution (HD) with hydroxyethystarch (HES130/0.4). After a standardized bone injury, animals randomly received 37.5, 75, 150, 300, 450 or 600 mg/kg fibrinogen (FGTW, LFB) or 500 ml of saline. Four hours later, a standardized liver injury was performed. Animals were then observed for two hours or until death. Blood loss was measured after death; Hemodynamic and coagulation parameters (thromboelastometry) were measured at baseline (BL), after HD, 15' 1, 2, 4 hours after fibrinogen administration and 2 hours after liver injury or right before the animals' death.

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Document Details

Document Type
Technical Report
Publication Date
Jan 01, 2014
Accession Number
ADA614717

Entities

People

  • Dietmar Fries
  • Judith Martini
  • Lisa Pilshofer
  • Sonja Maisch
  • Wenjun Martini
  • Werner Streif

Organizations

  • United States Army Institute of Surgical Research

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Analgesia
  • Anesthesia And Analgesia
  • Arteries
  • Blood
  • Blood Coagulation
  • Blood Coagulation Factors
  • Cardiovascular Physiological Phenomena
  • Cell Count
  • Fibrinogen
  • Health Services
  • Heart Rate
  • Measurement
  • Pressure Measurement
  • Statistical Analysis
  • Veins

Fields of Study

  • Medicine

Readers

  • Cardiovascular Physiology
  • Trauma Surgery or Emergency Medicine.