Targeting Pediatric Glioma with Apoptosis and Autophagy Manipulation

Abstract

Gliomas are the most common and most deadly solid tumors that affect children. Treatment options are limited and cure rates are dismal. My laboratory has established that Mer and Axl receptor tyrosine kinase are aberrantly overexpressed in gliomas, and that inhibition of these RTKs leads to increased glioma cell apoptosis, decreased tumor cell survival and profoundly improved chemosensitivity. However, I have also recognized that Mer and Axl inhibition is associated with increased autophagy. Based on this new discovery, I hypothesize that Mer and Axl RTK signaling regulates autophagy pathway activation in glioma cells, and this regulation determines the efficiency of glioma cell killing.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2014
Accession Number
ADA614915

Entities

People

  • Amy Keating

Organizations

  • University of Colorado Boulder

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Apoptosis
  • Autophagy
  • Biomedical Research
  • Cell Line
  • Cell Physiological Processes
  • Cells
  • Department Of Defense
  • Inhibition
  • Molecules
  • Neoplasms
  • Regulations
  • Small Molecules
  • Survival
  • Targeting
  • Therapy
  • Tyrosine

Fields of Study

  • Biology

Readers

  • Breast cancer cell signaling and growth regulation.
  • Cellular and Molecular Pathways of Apoptosis.
  • Oncology