Development of Practical and Rapid Field-Based Therapies for SCI

Abstract

We have designed a set of experiments to test candidate therapies for spinal cord injury (SCI) that could be applied in the battlefield and other acute traumatic settings. Specifically, we aim to optimize a combinatorial treatment to augment behavioral recovery following severe spinal cord contusion. These strategies include: 1) augmentation of the intrinsic growth state of an injured neuron by elevating cyclic AMP levels, and 2) modifying the extrinsic toxic/inhibitory spinal cord environment by transplantation of cells secreting growth factors.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Feb 01, 2014
Accession Number
ADA615117

Entities

People

  • John H. Brock
  • Mark H. Tuszynski

Organizations

  • University of California, San Diego

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Battlefields
  • Biomedical Research
  • Bone Marrow
  • Cells
  • Environment
  • Growth Factors
  • Recovery
  • Spinal Cord
  • Spinal Injuries
  • Stem Cells
  • Stromal Cells
  • Transplantation
  • Wounds And Injuries

Fields of Study

  • Medicine

Readers

  • Neuroscience
  • Trauma Surgery or Emergency Medicine.

Technology Areas

  • Biotechnology
  • Biotechnology - Cancer Biotech