Extracorporeal Membrane Oxygenation in a Patient With Refractory Acute Respiratory Distress Syndrome Secondary to Toxic Epidermal Necrolysis.
Abstract
Toxic epidermal necrolysis (TEN) is a rare condition affecting an estimated 1 to 2 cases per million per year, with reported mortality between 30% and 50% typically because of multiorgan failure or sepsis. Acute pulmonary complications from this disorder include bronchial mucosal sloughing, pulmonary edema, and infectious pneumonitis. Pulmonary complications in TEN occurred in 46% of patients in one series. Use of extracorporeal life support (ECLS) in adults with acute respiratory distress syndrome (ARDS) has increased markedly during the past few years after successful treatment in adults with swine flu (H1N1) and publication of the CESAR (conventional ventilation or ECMO for severe adult respiratory failure) trial, which demonstrated a lower mortality and disability at 6 months for patients referred to an ECLS center. The suggested ideal candidate for ECLS would be one with an acute, reversible, survivable illness if not for associated ARDS, no significant comorbidities, no contraindication to systemic anticoagulation, less than 8 days on mechanical ventilation, and younger than 65 years of age.
Document Details
- Document Type
- Technical Report
- Publication Date
- Dec 01, 2014
- Accession Number
- ADA615217
Entities
People
- Andriy I Batchinsky
- Booker T. King
- Christy R. Sine
- Evan M. Renz
- James E. Hull
- Jeffrey D. Mcneil
- Jeremy C. Pamplin
- Jeremy Cannon
- Josh Walker
- Kevin K Chung
- Stephen Derdak
Organizations
- United States Army Institute of Surgical Research