Systemic Review and Meta-analysis of Randomized Clinical Trials Comparing Primary vs Delayed Primary Skin Closure in Contaminated and Dirty Abdominal Incisions
Abstract
Surgical site infection (SSI) following abdominal surgery is common. When assessed actively and prospectively, it has been found to affect as many as 45% of patients. Furthermore,without active post discharge surveillance, up to 79% of SSI will be missed. Surgical site infection confers significant morbidity,with an additional risk of mortality. There are further health care related costs, through increased hospital stay, repeated surgery, nursing care costs, and drug treatment. Because of these factors, there is international interest in reducing the rate of SSI. To determine using meta-analysis whether delayed primary skin closure (DPC) of contaminated and dirty abdominal incisions reduces the rate of surgical infection compared with primary skin closure (PC). Delayed primary skin closure may reduce the rate of SSI, but current trials fail to provide definitive evidence based on poor design. Well-designed, large-numbered randomized clinical trials are warranted.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 26, 2013
- Accession Number
- ADA615218
Entities
People
- Aneel Bhangu
- Douglas M. Bowley
- Jonathan Lundy
- Prashant Singh
Organizations
- United States Army Institute of Surgical Research