Biological Activities of Fusarochromanone: a Potent Anti-cancer Agent

Abstract

Fusarochromanone (FC101) is a small molecule fungal metabolite with a host of interesting biological functions, including very potent anti-angiogenic and direct anti-cancer activity. Our data presented here indicates that FC101 is an excellent lead candidate for small molecule anti cancer agent that simultaneously affects angiogenesis signaling, cancer signal transduction, and apoptosis. further understanding of the underlying FC101's molecular mechanism may lead to the design of novel targeted and selective therapeutics, both of which are pursued targets in cancer drug discovery.

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Document Details

Document Type
Technical Report
Publication Date
Sep 03, 2014
Accession Number
ADA615221

Entities

People

  • Brian A. Salvatore
  • Brian D. Furmanski
  • Christopher G. Kevil
  • Elahe Mahdavian
  • Gopi K. Kolluru
  • John L. Clifford
  • Kaustubh N. Bhinge
  • Mansoureh Barzegar
  • Phillip Palyok
  • Quincy Quick
  • Shile Huang
  • Steven Adelmund
  • Tara W. Hart
  • Yang Wu
  • Ying Gu
  • Yong Yu Liu
  • Yoon Jee Kim

Organizations

  • United States Army Institute of Surgical Research

Tags

DTIC Thesaurus Topics

  • Apoptosis
  • Biological Sciences
  • Birds
  • Cell Line
  • Cell Physiological Processes
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Endothelial Cells
  • Epithelial Cells
  • Fungi
  • Molecular Biology
  • Molecules
  • Neoplasms
  • Proteins
  • Small Molecules
  • Tumor Cell Line

Fields of Study

  • Biology
  • Chemistry

Readers

  • Immunology
  • Molecular and Cellular Biochemistry
  • Oncology (Cancer Research).