The Parkinson's Registry Investigation of Diagnosis and Etiology (PRIDE) Study

Abstract

Exposure to pesticides, solvents or traumatic brain injury increase PD risk. This study takes advantage of the population-based PD registry in Santa Clara County, California and extensive state toxicants databases to investigate the causes of PD and PD-related morbidity and mortality. Study Design: Phase 1: The residence history of more than 3,000 PD cases from the population-based PD registry will be linked to geographically-specific exposure information to determine the relationship between toxicant exposure and PD incidence, morbidity and mortality using Cox proportional hazards regression with time-varying measures of chronic exposure, adjusting for confounding. Phase 2: Conduct a case-control study in a stratified random sample of cases and matched controls, collecting information on occupation, traumatic brain injury, and lifestyle risk factor information and conducting exams. Relevance: This work can help identify the causes and, ultimately, ways to prevent PD.

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Document Details

Document Type
Technical Report
Publication Date
Apr 01, 2015
Accession Number
ADA615937

Entities

People

  • Caroline M. Tanner

Organizations

  • Northern California Institute for Research and Education

Tags

DTIC Thesaurus Topics

  • Brain Injuries
  • California
  • Data Analysis
  • Databases
  • Dementia
  • Department Of Defense
  • Diseases And Disorders
  • Information Science
  • Information Security
  • Medical Personnel
  • Morbidity
  • Parkinson'S Disease
  • Public Health
  • Risk Factors
  • Statistical Samples
  • Statistics
  • Vital Statistics

Readers

  • Clinical Trial Research.
  • Molecular and genetic basis of cancer.
  • Neurodegenerative Parkinson's Disease and Rickettsial Disease handbook, including the data level of dopamine, BC, neurons, and PD.