Hydroxocobalamin Versus Sodium Thiosulfate for the Treatment of Acute Cyanide Toxicity in a Swine (Sus scrofa) Model

Abstract

Study Objective: We compare the efficacy of hydroxocobalamin to sodium thiosulfate to reverse the depressive effects on mean arterial pressure in a swine model of acute cyanide toxicity and gain a better understanding of the mechanism of action of the hydroxocobalamin in reversal of the toxicity.

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Document Details

Document Type
Technical Report
Publication Date
Jun 01, 2012
Accession Number
ADA616121

Entities

People

  • Anneke Bush
  • David A. Tanen
  • Julio R. Lairet
  • Patricia Dixon
  • Rebecca L. Pitotti
  • Vikhyat S Bebarta

Organizations

  • United States Army Institute of Surgical Research

Tags

DTIC Thesaurus Topics

  • Acid-Base Imbalance
  • Anesthesia
  • Arteries
  • Biological Sciences
  • Blood
  • Cardiovascular Physiological Phenomena
  • Cardiovascular System
  • Chemical Synthesis
  • Chemistry
  • Cyanides
  • Emergency Medicine
  • Heart Rate
  • Measurement
  • Oxygenation
  • Potassium Cyanide
  • Saline Solution
  • Toxicity

Readers

  • Cardiovascular Physiology
  • Neurodegenerative Parkinson's Disease and Rickettsial Disease handbook, including the data level of dopamine, BC, neurons, and PD.
  • Toxicology/Environmental Toxicology