CG-MS/MS Analyses of Biological Samples in Support of Developmental Toxic Effects on Whole-Body Exposure of Rats to GB

Abstract

This report documents the results of gas chromatography tandem mass spectrometry analyses of blood, tissues, and organs (heart, lung, liver, kidney, brain, eye, and diaphragm), which were obtained from rats (postnatal days 14, 21, 42, and 70) after their exposure to various concentrations of sarin (GB) using the whole-body inhalation system for 60 min. The amount of free and regenerated GB present in these biological samples was quantified using chemical ionization mass spectrometry with isotope dilution.

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Document Details

Document Type
Technical Report
Publication Date
Mar 01, 2015
Accession Number
ADA616556

Entities

People

  • Jeffrey M. Mcguire
  • Michael W. Busch
  • Paul S. Demond

Organizations

  • Edgewood Chemical Biological Center

Tags

DTIC Thesaurus Topics

  • Acetylcholinesterases
  • Chemical Warfare
  • Chemical Warfare Agents
  • Chromatography
  • Department Of Homeland Security
  • Gas Chromatography
  • Health Services
  • Magnetic Resonance
  • Mass Spectra
  • Mass Spectrometry
  • Materials
  • Medical Personnel
  • Nerve Agents
  • Nervous System
  • Spectrometry
  • Spectroscopy
  • Tissues

Fields of Study

  • Chemistry

Readers

  • Cardiovascular Physiology
  • Neuroscience
  • Neurotoxicology