Characteristics of Mild Dengue Virus Infection in Thai Children
Abstract
A four-year longitudinal cohort and geographic cluster study in rural Thailand was conducted to characterize the clinical spectrum of dengue virus (DENV) infection. Symptomatic DENV infections in the cohort were detected by active school absence based surveillance that triggered cluster investigations around ill cohort children. Data from 189 cohort children with symptomatic DENV infection and 126 contact children in the clusters with DENV infection were analyzed. Of infected contacts, only 19% were asymptomatic; 81% were symptomatic, but only 65.9% reported fever. Symptom-based case definitions were unreliable for diagnosis. Symptomatic infections in contacts were milder with lower DENV RNA levels than the cohort. Infections in contacts with fever history were more likely to have detectable DENV RNA than infections without fever history. Mild infections identified by cluster investigations account for a major proportion of allDENV infections. These findings are relevant for disease burden assessments, transmission modeling, and determination of vaccine impact.
Document Details
- Document Type
- Technical Report
- Publication Date
- Dec 01, 2013
- Accession Number
- ADA616665
Entities
People
- Ananda Nisalak
- Anon Srikiatkhachorn
- Darunee Buddhari
- Jared Aldstadt
- Laura Hermann
- Piraya Bhoomiboonchoo
- Richard G Jarman
- Suwich Thammapalo
- Thomas W Scott
- Yin-kyu Yoon
Organizations
- Armed Forces Research Institute of Medical Sciences