Physiological Challenges of Bone Repair

Abstract

Bone healing after fracture occurs in a well organized manner and involves a multitude of cell types, inflammatory cytokines, growth factors, prostaglandins, and certain vitamins. Some of the means by which alterations in these essential components affect bone repair are understood, whereas others still need to be delineated. Based on clinical experience and basic science research, certain clinical conditions have become associated with delays in bone repair after fracture. These conditions include chronic inflammation, diabetes, hypovitaminosis, aging, and polytrauma. This brief report reviews some of the ways by which these conditions have been shown to negatively influence bone repair.

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Document Details

Document Type
Technical Report
Publication Date
Dec 01, 2012
Accession Number
ADA616971

Entities

People

  • Chris Pape
  • David Hak
  • Joseph Borrelli Jr.
  • Joseph Hsu
  • Joseph R. Lane
  • Peter Giannoudis
  • Sheldon Lin

Organizations

  • United States Army Institute of Surgical Research

Tags

DTIC Thesaurus Topics

  • Biological Factors
  • Bone And Bones
  • Bone Diseases
  • Cells
  • Gene Expression
  • Growth Factors
  • Health Services
  • Medical Personnel
  • Osteogenesis
  • Peptide Growth Factors
  • Peptides
  • Proteins
  • Stem Cells

Fields of Study

  • Medicine

Readers

  • Immunology and Pathology
  • Neurotrauma and Rehabilitation Medicine.
  • Systems Analysis and Design