Prolonged Release of the Local Anesthetic Butamben for Potential Use in Pain Management

Abstract

Continuous delivery of local anesthetics might be useful for management of localized and chronic pain. Controlled release injectable anesthetics have been developed but they can deliver the drug for only few days and the release is not zero-order. A drug delivery system (DDS) consisting of a perforated reservoir for drug containment and release and its potential for management of chronic pain is described. Proof of principle is detailed for long-term zero order delivery of butamben. In this study, the DDS was a polyimide tube with a 0.20 mm hole and butamben release was evaluated in vitro. It is envisioned that the DDS could be implanted in proximity to a nerve, enervating the pain source, for long-term control of chronic pain.

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 2012
Accession Number
ADA618511

Entities

People

  • Ashish Rastogi
  • Phillip D. Bowman
  • Salomon Stavchansky

Organizations

  • United States Army Institute of Surgical Research

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Anesthetics
  • Contracts
  • Drug Therapy
  • Health Services
  • Information Operations
  • Local Anesthetics
  • Pain
  • Pain Management
  • Pharmacies
  • Pharmacology
  • Therapy
  • United States

Fields of Study

  • Medicine

Readers

  • Computer Science/Computer Engineering/Data Science/Digital Signal Processing.
  • Trauma Surgery or Emergency Medicine.