Validation of Biomarkers of the Tumor Microenvironment

Abstract

The goals of the first year of the funding period were to develop methods for the analysis of FFPE (formalin-fixed paraffin-embedded) prostate cancer biopsy tissue in order validate the accuracy of a stroma-based classifier for diagnosis of prostate cancer using FFPE anatomically negative biopsies. The methods that needed to be developed were PCR primers that operate on RNA retrieved from FFPE prostate cancer tissue and to apply the primers as a microarray to accurately detect RNA corresponding to the primer targets. Proof-of-principal for these goals has been achieved.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2014
Accession Number
ADA618522

Entities

People

  • Dan Mercola

Organizations

  • University of California, Irvine

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Accuracy
  • Alkanes
  • Biological Markers
  • Biomedical Research
  • Classification
  • Clinical Trials
  • Design Criteria
  • Machine Learning
  • Neoplasms
  • Prostate
  • Prostate Cancer
  • Radiotherapy
  • Tissues
  • Training
  • United States
  • Validation

Fields of Study

  • Biology

Readers

  • Molecular Genetics
  • Molecular and genetic basis of cancer.
  • Software Engineering