Multimodal Approach to Testing the Acute Effects of Mild Traumatic Brain Injury (mTBI)
Abstract
The objective of the study is to develop a multimodal approach to assess concussion in the acute phase of injury. This first full year of the project has included several key staff changes, a major instrument acquisition, repairs and upgrades to the MEG, combined with substantial progress with patient recruitment and results that shed light on the primary study goals. We were referred a total of 25 patients from the Hospital, and consented a total of 15 patients, 3 of whom have dropped out. Six with mTBI and six non-head trauma controls have been studied. The first analysis compared acute mTBI patients to non-head trauma controls in the first days after injury. Multiple modalities of behavioral, electrophysiological, and most strikingly, MEG changes were found. The MEG of all mTBI patients had delta activity in the frontal lobes that was absent in all controls. A scientific abstract on these findings has been accepted for publication and these results may be the forerunner of an objective test for acute concussion. Analysis of this data one month after injury when symptoms after mTBI had resolved, is ongoing. This one-month data may provide evidence of neuronal damage recovery from the trauma; objective demonstration of improvement would have exciting potential for predicting and monitoring recovery after acute brain trauma, compared to the persistent delta waves reported in the majority of chronic TBI patients.
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 01, 2015
- Accession Number
- ADA619146
Entities
People
- Michael G. Harrington
Organizations
- Huntington Hospital