In Vivo Modeling of Biofilm-Infected Wounds: A Review
Abstract
Chronic wounds are a significant and growing problem in healthcare today. Bacterial biofilms are a key factor whose importance to wound chronicity and persistence has only recently become widely appreciated. A bacterial biofilm can be defined as a complex community of aggregated bacteria embedded within a self secreted matrix of extracellular polymeric substance, or EPS. Although a rapidly growing field of study, there remains an immense gap in basic knowledge about many aspects of biofilm behavior and formation, particularly in the in vivo setting. The lack of adequate in vivo models has made it difficult to faithfully model wound biofilms. We believe that an appropriate, consistent, and translatable in vivo model of wound biofilm should possess several different, but important, characteristics upon which the strength of a model can be determined.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 15, 2012
- Accession Number
- ADA619186
Entities
People
- Akhil K. Seth
- Kai Poon Leung
- Matthew R. Geringer
- Robert D. Galiano
- Seok J. Hong
- Thomas A. Mustoe
Organizations
- United States Army Institute of Surgical Research