A Novel Therapeutic for the Treatment and Prevention of Hearing Loss from Acoustic Trauma
Abstract
The most significant finding during this research period was that our therapeutic peptide, T1/P13, was efficacious in treating permanent and severe noise induced hearing loss. Using a steady-state model of noise exposure (117 db for 2 hours), T1/P13 was administered one hour after noise using a variety of doses and routes of administration. Both topical (ear drop} and subcutaneous (SQ} routes of administration of T1/P13 resulted in a reduction in hearing loss seen after noise insult, with the most dramatic improvement seen after SQ administration .
Document Details
- Document Type
- Technical Report
- Publication Date
- May 01, 2015
- Accession Number
- ADA619546
Entities
People
- Sharon Mccoy
- Steven H. Hefeneider