Optimal Treatment of Malignant Long Bone Fracture: Influence of Method of Repair and External Beam Irradiation on the Pathway and Efficacy of Fracture Healing

Abstract

The purpose of this project is to characterize the differential effects of radiation on the two pathways of fracture healing in an established animal model of bilateral femur fracture repair. Since relocation to MUSC, the PI has been fully engaged in securing suitable facilities, collaborations, and related institutional regulatory approvals to implement the animal model at MUSC. This was accomplished in August, 2013. Surgical procedures consisting of bilateral femur fracture and repair have been completed on both cohorts of 18 animals in the year 1 SOW; all animals were imaged and have been sacrificed according to protocol schedule. Group I specimens are being analyzed with micro CT to assess callus volume and character. Group II specimens are being processed for RNA isolation and PCR array analysis. Year 2 SOW animal procedures in Group III will begin on schedule in the fifth quarter of the award.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2014
Accession Number
ADA619625

Entities

People

  • E. L. Hanna
  • Vincent D. Pellegrini Jr.

Organizations

  • Medical University of South Carolina

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Batch Processing
  • Biomedical Research
  • Bone Cancer
  • Bone Diseases
  • Bone Fractures
  • Department Of Defense
  • Diseases And Disorders
  • Electronic Mail
  • Information Operations
  • Musculoskeletal Diseases
  • Neoplasms
  • Osteogenesis
  • Pcr Testing
  • Radiation
  • South Carolina

Readers

  • Neurotrauma and Rehabilitation Medicine.
  • Oncology (Cancer Research).
  • Trauma Surgery or Emergency Medicine.