Immunogenicity of One Dose of Vero Cell Culture-Derived Japanese Encephalitis (JE) Vaccine in Adults Previously Vaccinated with Mouse Brain-Derived JE Vaccine

Abstract

Background: There are no data on the use of inactivated Vero cell culture-derived Japanese encephalitis (JE) vaccine (JE-VC) as a booster among individuals who previously received inactivated mouse brain-derived JE vaccine (JE-MB). Methods: Military personnel who received 3 doses of JE-MB or were JE vaccine-na ve were vaccinated with 2 doses of JE-VC on days 0 and 28. Serum neutralizing antibodies were measured pre-vaccination and 28 days after each dose. Non-inferiority was evaluated for seroprotection rate and geometric mean titer (GMT) between previously vaccinated participants post-dose 1 and vaccine-na ve participants post-dose 2. Results: Fifty-three previously vaccinated and 70 JE vaccine-na ve participants were enrolled. Previously vaccinated participants had significantly higher GMTs pre-vaccination, post-dose 1, and post-dose 2. Seroprotection rates among previously vaccinated participants post-dose 1 (44/44, 100%) were noninferior to those achieved in previously na ve participants post-dose 2 (53/57, 93%). The GMT was significantly higher in previously vaccinated participants post-dose 1 (GMT 315; 95% CI 191 520) compared to previously na ve participants post-dose 2 (GMT 79; 95% CI 54 114). Conclusions: Among military personnel previously vaccinated with 3 doses of JE-MB, a single dose of JE-VC adequately boosts neutralizing antibody levels and provides at least short-term protection. Additional studies are needed to confirm these findings in other populations and determine the duration of protection following a single dose of JE-VC in prior recipients of JE-MB.

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Document Details

Document Type
Technical Report
Publication Date
Mar 06, 2012
Accession Number
ADA619733

Entities

People

  • Barbara W. Johnson
  • Brad J. Biggerstaff
  • Dennis J. Faix
  • J. E. Staples
  • M. Fischer
  • Michael Sracic
  • Olga I. Kosoy
  • Randall J. Nett
  • Tabitha Woolpert

Organizations

  • Naval Health Research Center

Tags

DTIC Thesaurus Topics

  • Antibodies
  • Culture Techniques
  • Data Science
  • Diseases And Disorders
  • Encephalitis
  • Health Services
  • Hepatitis
  • Immunogenicity
  • Infectious Diseases
  • Medical Personnel
  • Military Personnel
  • Side Effects
  • Statistical Analysis
  • United States
  • Vaccination
  • Vaccines
  • Viruses

Fields of Study

  • Medicine

Readers

  • Immunology
  • Mental Health of Military Veterans with Posttraumatic Stress Disorder (PTSD): Risk Factors, Prevalence, Symptoms, and Treatment.

Technology Areas

  • Biotechnology