Broad Spectrum Respiratory Pathogen Analysis of Throat Swabs from Military Recruits Reveals Interference Between Rhinoviruses and Adenoviruses
Abstract
Military recruits experience a high incidence of febrile respiratory illness (FRI), leading to significant morbidity and lost training time. Adenoviruses, group A Streptococcus pyogenes, and influenza virus are implicated in over half of the FRI cases reported at recruit center clinics. The etiology of the remaining cases remains unclear. In this study, we explore the background carriage rates of rhinoviruses, Streptococcus pneumoniae, Haemophilus influenzae, and Neisseria meningitidis. The results showed that S. pneumoniae, H. influenzae, and N. meningitidis were widely distributed in 86%, 82%, and 76% of recruits, respectively. Rhinovirus was identified in 43% of recruits. Asymptomatic (healthy) recruits were as likely as ill recruits to be positive for all four of these organisms, suggesting that they are not responsible for significant illness in training populations. Recruits with FRI were actually somewhat less likely to carry rhinovirus than healthy recruits, the apparent result of a negative association between adenovirus carriage and rhinovirus carriage. This intriguing discovery may result from temperature repression of rhinoviruses (which are highly temperature sensitive) by the fevers induced by adenovirus infection.
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 09, 2010
- Accession Number
- ADA619734
Entities
People
- Anthony P. Malanoski
- Baochuan Lin
- Christian J. Hansen
- David A. Stenger
- Jason Brown
- Kate M. Blaney
- Michael Broderick
- Nina C. Long
- Tomasz Leski
- Zheng Wang
Organizations
- Naval Health Research Center