Smooth Constrained Heuristic Optimization of a Combinatorial Chemical Space
Abstract
Several algorithms for optimizing a combinatorial subspace of chemical compound space with constraints are compared. The test system is a library of organic chromophores for electro-optic applications. The hyperpolarizability is maximized while the absorption in the range of 400-700 nm is constrained to zero. The best payoff in terms of primary objective, feasibility, and computational cost is achieved using a heuristic reordering of orthogonal search directions.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 01, 2015
- Accession Number
- ADA620145
Entities
People
- Berend C. Rinderspacher
Organizations
- United States Army Research Laboratory