Dendrimer-Silver Complexes and Nanocomposites as Antimicrobial Agents

Abstract

Silver complexes of poly(amidoamine) (PAMAM) dendrimers as well as different {silver-PAMAM} dendrimer nanocomposite solutions have been tested in vitro against Staphylococcus aureus, Pseudomonas aeruginosa, and Escherichia coli bacteria, using the standard agar overlay method. Both PAMAM silver salts and nanocomposites displayed considerable antimicrobial activity without the loss of solubility and activity, even in the presence of sulfate or chloride ions.

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Document Details

Document Type
Technical Report
Publication Date
Jan 01, 2001
Accession Number
ADA620206

Entities

People

  • Albert T. Mcmanus
  • Donald A. Tomalia
  • Douglas R. Swanson
  • Gary L. Hagnauer
  • Lajos Balogh

Organizations

  • United States Army Institute of Surgical Research

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Absorption
  • Anti-Bacterial Agents
  • Anti-Infective Agents
  • Bacteria
  • Dendrimers
  • Dermatologic Agents
  • Electronic Mail
  • Macromolecules
  • Materials
  • Metals
  • Microorganisms
  • Nanocomposites
  • Nanotechnology
  • Silver Compounds
  • Standards
  • Staphylococcus Aureus
  • Transition Metals

Fields of Study

  • Materials science

Readers

  • Microbial Pathology
  • Polymer Science and Technology
  • Surface Engineering/Surface Coating Technology.