Streptococcus pneumoniae Biofilm Formation Is Strain Dependent, Multifactorial, and Associated with Reduced Invasiveness and Immunoreactivity during Colonization

Abstract

Biofilms are thought of play an important role during colonization of the nasopharynx by Strptococcus pneumoniae, yet how they form in vivo and the determinants responsible remain unknown. Using scanning electron microscopy, we show that biofilm aggregates of increasing complexity form ion murine nasal septa following intranasal inoculation. These biofilms were highly distinct from in vitro biofilms, as they were discontiguous and appeared to incorporate nonbacterial components such as intact host cells.

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Document Details

Document Type
Technical Report
Publication Date
Oct 15, 2013
Accession Number
ADA620213

Entities

People

  • Anel Lizcano
  • Carlos J. Orihuela
  • Carlos J. Sanchez
  • Carmen Munoz-almagro
  • Cecilia A. Hinojosa
  • Krystle Blanchette-cain
  • Molly A. Bergman
  • Norberto Gonzalez-juarbe
  • Ramya A. Babu

Organizations

  • United States Army Institute of Surgical Research

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Availability
  • Classification
  • Contracts
  • Electron Microscopy
  • Electrons
  • Information Operations
  • Inoculation
  • Instructions
  • Microscopy
  • Monitoring
  • Nasopharynx
  • Optical Analysis
  • Scanning Electron Microscopy
  • Streptococcus
  • United States

Fields of Study

  • Biology

Readers

  • Immunology
  • Microbial Pathology
  • Oncology (Cancer Research).

Technology Areas

  • Biotechnology
  • Microelectronics