Determining the Molecular and Genetic Basis for Diabetes in Navy Bottlenose Dolphins (Tursiops truncatus)
Abstract
CREB-ZF functions as a transcriptional represser, at least in terms of its effects on gluconeogenic genes. Efforts are underway to determine whether CREB-ZF directly interferes with activation of the cAMP-responsive factor CREB or the CRTC family of CREB coactivators. CREB-ZF has been reported to modulate the unfolded protein response (UPR) although the underlying mechanism is unclear. Because it contains a leucine zipper DNA binding domain, CREB-ZF would be expected to compete for binding to CREB binding sites. We will test whether CREB-ZF displaces CREB and CRTC2 from gluconeogenic promoters and thereby reduces hepatic glucose production.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 12, 2015
- Accession Number
- ADA620249
Entities
People
- Marc R. Montminy
Organizations
- Salk Institute for Biological Studies