Evaluation of In Vitro Cross-Reactivity to Avian H5N1 and Pandemic H1N1 2009 Influenza Following Prime Boost Regimens of Seasonal Influenza Vaccination in Healthy Human Subjects: A Randomised Trial
Abstract
Recent studies have demonstrated that inactivated seasonal influenza vaccines (IIV) may elicit production of heterosubtypic antibodies, which can neutralize avian H5N1 virus in a small proportion of subjects. We hypothesized that prime boost regimens of live and inactivated trivalent seasonal influenza vaccines (LAIV and IIV) would enhance production of heterosubtypic immunity and provide evidence of cross-protection against other influenza viruses.
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 26, 2013
- Accession Number
- ADA620254
Entities
People
- Amporn Limsalakpetch
- Anan Jongkaewwattana
- Arunee Thitithayanont
- David Saunders
- Delia Bethell
- Jarin Kramyu
- Kosol Yongvanitchit
- Nichapat Uthaimongkol
- Suwimon Wiboon-ut
- Utaiwan Kum-arb
Organizations
- Armed Forces Research Institute of Medical Sciences