Targeted Magnetic Hyperthermia for Lung Cancer

Abstract

The hypothesis of this research is that inhalable SPIO nanoparticles surface-functionalized with EGFR targeting ligand, when exposed to an appropriate magnetic field, will enable highly efficient and specific tumor cell death by hyperthermia. In the final year (no-cost extension) of this research program, we have demonstrated that aggregation state of iron oxide nanoparticles significantly affects the therapeutic efficacy. Larger, micron-size aggregates induce necrosis while nano-size aggregates induce apoptosis. Further, micron-size aggregates are more effective in inhibiting tumor growth a mouse tumor model. Overall, our studies show that magnetic hyperthermia using SPIO nanoparticles is a promising strategy to treat lung cancer.

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Document Details

Document Type
Technical Report
Publication Date
Nov 01, 2014
Accession Number
ADA620276

Entities

People

  • Jayanth Panyam

Organizations

  • University of Minnesota

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Antineoplastic Agents
  • Carcinoma
  • Cell Physiological Processes
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Health Services
  • Magnetic Fields
  • Medical Personnel
  • Metal Oxide Nanoparticles
  • Oncology
  • Organic Chemistry

Fields of Study

  • Medicine

Readers

  • Materials Science and Engineering.
  • Nanocomposite Materials Science
  • Oncology (Cancer Research).

Technology Areas

  • Biotechnology
  • Biotechnology - Cancer Biotech