Targeting Prostate Cancer with Bifunctional Modulators of the Androgen Receptor
Abstract
The overall goal of this research project is to develop and implement a conceptually innovative strategy for down-regulating androgen receptor: the creation of bifunctional molecules that simultaneously bind to the androgen receptor and to bromodomain proteins Brd4. In this way, genes that are typically regulated by androgen receptor and glucocorticoid receptor will be extrinsically controlled. In this final year of funding, we completed the functional characterization of agonist and antagonist-based bi-functional recruiters. Importantly, we have a suite of recruiters that show context specificity. In the extension period of the work, we are completing RNAseq experiments to gain a complete understanding of the context specificity of this exciting class of molecules.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2014
- Accession Number
- ADA620319
Entities
People
- Aaron Van Dyke
- Anna K. Mapp
- James Carolan
- Steven Sturlis
Organizations
- University of Michigan