Prevention of Blast-Related Injuries

Abstract

This report covers work done on blast testing of live anesthetized swine and on unembalmed cadavers. A detailed histological study of blast-exposed swine brain showed that there was damage to both the axons and the neuron cell bodies in the form beta-APP immunoreactivity and other tests, suggesting that the mechanism of injury may be different from that of blunt impact. We have also developed computer models of the swine and human brain and are in the process of validating them against the acquired experimental data. It is proposed that future research concentrate on seeking injury mechanisms to brain cells caused by a pressure wave.

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Document Details

Document Type
Technical Report
Publication Date
Jul 14, 2015
Accession Number
ADA620348

Entities

People

  • Albert I. King
  • Feng Zhu
  • John Cavanaugh
  • King Yang
  • Liying Zhang
  • Xin Jin

Organizations

  • Wayne State University

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Alzheimer Disease
  • Brain
  • Brain Injuries
  • Cardiovascular Physiological Phenomena
  • Cells
  • Computers
  • Data Mining
  • Experimental Data
  • Explosives
  • Fungi
  • Histology
  • Military Medicine
  • Neurodegeneration
  • Neuroimaging
  • Neurology
  • Neurosciences
  • Test Methods

Readers

  • Cardiovascular Physiology
  • Neuroscience
  • Neurotrauma and Rehabilitation Medicine.