Cortical Lesions as Determinants of White Matter Lesion Formation and Cognitive Abnormalities in MS

Abstract

This study evaluates for the presence of connectivity between cortical lesions and white matter lesions in patients with MS. During the report period, we have statistically documented this connectivity, presented our findings at 2 national meetings, and have submitted a paper to Neurology. Using one of our novel imaging sequences, we have documented a characteristic halo around larger MS lesions that seems specific to MS. We are currently collecting and analyzing data from our positive control cohort to confirm that this finding is not noted with other types of white matter pathology. Both lesion connectivity and MS lesion halos may serve as novel new imaging biomarkers for the disease. We have explored automated cortical lesion detection. We have begun preparation for tract-based and normal-appearing white matter analysis using DTI derived metrics as well as image intensity ratios.

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Document Details

Document Type
Technical Report
Publication Date
May 01, 2015
Accession Number
ADA620529

Entities

People

  • John D. Port

Organizations

  • Mayo Clinic

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Abnormalities
  • Acquisition
  • Biological Markers
  • Biomedical Research
  • Computers
  • Data Acquisition
  • Data Analysis
  • Data Processing
  • Detection
  • Detectors
  • Magnetic Resonance
  • Multiple Sclerosis
  • Neurology
  • Patent Applications
  • Patents
  • Sequences
  • Statistical Analysis

Readers

  • Medical Imaging.