Simulation of Blast Loading on an Ultrastructurally-based Computational Model of the Ocular Lens

Abstract

Research progress over the past year focused on imaging of lens fiber cell structure using confocal laser scanning microscopy (CLSM), and type IV collagen structure using cryo-electron microscopy and tomography (cryo-EM and ET). The CLSM has demonstrated the ability to generate good structural identification of lens fiber cells at 10X objective, while the cryo- EM and ET have not yet positively identified type IV collagen structure of the lens capsule. The collaborations with Dr. Vernerey of CU Boulder on large deformation multiscale Lagrangian-Eulerian computational modeling of the whole lens, and Dr. Burd at the University of Oxford on multiscale modeling of the lens capsule, will lead to positive steps toward developing a multiscale model of the ocular lens.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2014
Accession Number
ADA620642

Entities

People

  • Richard A Regueiro

Organizations

  • University of Colorado Boulder

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Bioengineering
  • Biomedical Engineering
  • Cell Structure
  • Cells
  • Cellular Structures
  • Collagen
  • Computational Modeling
  • Confocal Laser Scanning Microscopy
  • Developmental Biology
  • Electron Microscopy
  • Engineering
  • Experimental Data
  • Mechanical Engineering
  • Microscopy
  • Multiscale Modeling
  • Thickness
  • Three Dimensional

Fields of Study

  • Physics

Readers

  • Computational Fluid Dynamics (CFD)
  • Image Processing and Computer Vision.
  • Oncology (Cancer Research).

Technology Areas

  • Directed Energy
  • Microelectronics