SCI with Brain Injury: Bedside to Bench Modeling for Developing Treatment and Rehabilitation Strategies
Abstract
Spinal cord injury (SCI) is often accompanied by traumatic brain injury (TBI), but evidence- based approaches for treatment of this dual- diagnosis are lacking. We used clinical- practice evidence to guide development of an animal model for studying the dual injury to open new directions for therapy. We made an animal model that showed unexpected interactions between these injuries. We then built a clinical TBI+SCI patient database from San Francisco General Hospital, the Santa Clara Valley Medical Center and from the VA Palo Alto Health Care System, covering acute and chronic stages of recovery. Common data elements were made for querying patient records, resulting in an overview of recovery and showing that more medications are used in the dual- diagnosis patients than either injury alone. Agents tested in the new model showed that drug effects differ with injury type. The project has resulted in a continuing community of practice and research, and the animal model should continue to inform and be informed by the clinical enterprise.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2013
- Accession Number
- ADA620801
Entities
People
- Michael S Beattie
Organizations
- University of California, San Francisco