The Role of IL-17 in the Angiogenesis of Rheumatoid Arthritis
Abstract
In this proposal we show that ligation of IL-17 to IL-17R plays a critical role in rheumatoid arthritis (RA) joint vascularization. However, less is known about the pro-angiogenic factors downstream of IL-17 cascade that could indirectly contribute to RA angiogenesis. In this progress report, we discovered a novel chemokine (CCL28) and its corresponding receptor (CCR10) that is modulated by IL-17 in RA myeloid cells. We uncover for the first time the expression pattern, regulation and function of this IL-17 downstream pathway. We further provide strong evidence that supports utilizing the CCL28/CCR10 cascade as a potential therapeutic target in RA. These findings were recently published in the highest ranked rheumatology journal (Annals of Rheumatic Disease) and the discoveries were highlighted in 11 other scientific journals.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 2015
- Accession Number
- ADA620940
Entities
People
- Seung-jae Kim
- Shiva Shahrara
- Zhenlong Chen
Organizations
- University of Illinois at Chicago