Probing Tumor Microenvironment with In Vivo Phage Display

Abstract

We have performed multiple phage screens in search for carcinoma-associated fibroblast (CAF)-targeting peptides utilizing the tumor-penetrating phage display technology combined with next generation phage DNA sequencing. We have identified at least 4 potentially novel CAF/stroma-targeting peptides. One of the peptides, CIS, homed to breast tumor stroma in two mouse models, and the homing was significantly enhanced by iRGD co-injection.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 2014
Accession Number
ADA621073

Entities

People

  • Erkki Ruoslahti

Tags

DTIC Thesaurus Topics

  • Biomedical Research
  • Blood
  • Blood Vessels
  • Bone Marrow
  • Breast Cancer
  • Cell Line
  • Cells
  • Coliphages
  • Demographic Cohorts
  • Dna Sequence Analysis
  • Fibroblasts
  • Identification
  • Lymphatic Vessels
  • Macrophages
  • Neoplasms
  • Stem Cells
  • Targeting

Fields of Study

  • Biology

Readers

  • Molecular Genetics
  • Oncology (Cancer Research).