A SOF Damage Control Resuscitation Cocktail

Abstract

The goal of this project is to develop a new damage control resuscitation (DCR) cocktail for use by SOF's that is capable of improving survival from polytrauma in austere settings. The cocktail components include Hextend for volume resuscitation and tissue perfusion, fibrinogen concentrate for hemostasis, and tranexamic acid for hemostasis. These components are tested in a combat-relevant swine polytrauma model of hemorrhagic shock with traumatic brain injury, free internal bleeding from an aortic tear, and femur fracture. Model development and validation, and objective 1 and 2 have been initiated in year 1 with an official project start date of April 15, 2014. The project has met with one primary scientific hurdle which has been overcome by adding vasopressin to the model to encourage more bleeding. We expect completion of this project to be on time and within budget.

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Document Details

Document Type
Technical Report
Publication Date
May 01, 2015
Accession Number
ADA621294

Entities

People

  • Nathan J White

Organizations

  • University of Washington

Tags

DTIC Thesaurus Topics

  • Biomedical Research
  • Blood
  • Brain Injuries
  • Cardiovascular Physiological Phenomena
  • Data Analysis
  • Department Of Defense
  • Fibrinogen
  • Hemorrhage
  • Hemorrhagic Shock
  • Hemostasis
  • Perfusion
  • Pituitary And Hypothalamic Hormones And Analogues
  • Proteins
  • Resuscitation
  • Survival
  • Validation

Fields of Study

  • Medicine

Readers

  • Trauma Surgery or Emergency Medicine.