VRP09 Objective Methods to Test Visual Dysfunction in the Presence of Cognitive Impairment
Abstract
Purpose: to develop and validate objective tests to diagnose vision deficits in patients with cognitive impairment and ensure effective monitoring of their treatment. Scope: objective methods to monitor visual function include 1) the pupil light reflex (PLR), 2) light evoked potentials (VEP) from the brain and from the eye and 3) purposeful eye movements to track moving targets that are resolved. Major Findings (year 4): i) determined that the melanopsin mediated pupil response, derived from the differential sustained pupil response to blue light vs. red light, correlates highly with retinal ganglion cell layer thickness derived from optical coherence tomography (OCT) in eyes with optic neuropathy, ii) in terms of the red-blue pupil light reflex test, showed that the resulting responses measured with our custom DynaScan-Smart Eye system correlate well with results obtained with the clinically-used Neuroptics DP-2000 system, iii) found that a patient has greater difficulty to stay fixated on a fixation target during stimulation of a diseased eye. Significance: objective tests of vision will greatly improve eye care by providing faster, lower cost testing that can be performed in remote settings and will provide a new tool for assessing innovative treatments being developed to save or restore vision.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2014
- Accession Number
- ADA621312
Entities
People
- Pieter Poolman
- Randy H. Kardon
Organizations
- University of Iowa