Vision Integrating Strategies in Ophthalmology and Neurochemistry (VISION)
Abstract
The overall goal of the VISION project is to discover neuroprotective strategies in three separate mouse models of injury to the visual axis, in order to identify potential candidates for the treatment of combat eye injuries and preserve vision in our injured warfighters. We have established three different mouse models of ocular injury with different injury initiating mechanisms (i.e. optic nerve crush, retinal ischemia/reperfusion, and chronic ocular hypertension). We have developed techniques to quantify damage to the retina, optic nerve, and visual axis in the brain (i.e. superior colliculus) that are damaged in these three models. We are testing neuroprotective agents and strategies, including neuroprotective estrogens, sigma-1 agonists, Brn3b, inhibitors of Jun N-terminal kinase (JNK), and inhibitors of protein stress to determine their efficacy in protecting the retina, optic nerve and superior colliculus from the damage induced by each of the 3 models.
Document Details
- Document Type
- Technical Report
- Publication Date
- Feb 01, 2014
- Accession Number
- ADA621384
Entities
People
- Abbot Clark
- Thomas Yorio
Organizations
- University of North Texas Health Science Center