Early Identification of Molecular Predictors of Heterotopic Ossification Following Extremity Blast Injury with a Biomarker Assay
Abstract
Following a traumatic orthopaedic injury, the affected muscle tissue is susceptible to a disease known as heterotopic ossification (HO), which is characterized by the formation of bone in the soft tissue. This disease is especially common in soldiers that have sustained severe injuries during military operations. The current studies are directed at identifying early- appearing biomarkers in the animal model that predict the occurrence of HO in the animal model and may well similarly predict the development of HO in the human condition. Patients exhibiting biomarkers predictive of exuberant HO formation can then be identified before the disease process begins and treated prophylactically.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2014
- Accession Number
- ADA621480
Entities
People
- Leon J. Nesti
Organizations
- Henry M. Jackson Foundation for the Advancement of Military Medicine