Virus Directed Assembly of Peptide Receptor Surfaces for Diverse Sensing Platforms and Applications

Abstract

The goal of this study has been to develop Tobacco mosaic virus (TMV) and its derived virus-like-particle (VLP) as a universal platform for the assembly, display and integration of receptor layers onto sensitive and robust transducer systems for biological and chemical detections. Unique features of this system include its genetic programmability, self-assembly, multivalent display capabilities and ability to be integrated with a range of transducer surfaces, including chip based ELISA, optical disk resonators, impedance electrodes and square wave electrochemical platforms. Combined these investigations have provided the basic knowledge needed to develop highly flexible and cost-effective receptor layers that are compatible with a range of target molecules and can be easily integrated within highly sensitive micro- and nano-system sensing platforms.

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Document Details

Document Type
Technical Report
Publication Date
Jul 29, 2014
Accession Number
ADA621610

Entities

People

  • James N Culver
  • Reza Ghodssi

Organizations

  • University of Maryland

Tags

Communities of Interest

  • Advanced Electronics
  • Materials and Manufacturing Processes

DTIC Thesaurus Topics

  • Abstracts
  • Agreements
  • Assembly
  • Biomolecules
  • Chemical Detection
  • Detection
  • Detectors
  • Diffusion
  • Diffusion Coefficient
  • Electron Beam Lithography
  • Engineering
  • Impedance
  • Nanotechnology
  • Particles
  • Self Assembly
  • Students
  • Transducers

Readers

  • Microwave Engineering.
  • Molecular and Cellular Biochemistry
  • Nanoscale Plasmonic Nanotechnology

Technology Areas

  • Biotechnology