Using Click Chemistry to Identify Potential Drug Targets in Plasmodium

Abstract

Sporozoite infection of the liver is the first obligate step of the Plasmodium mammalian cycle. Inhibiting this step can block malaria at an early step. However, few anti-malarials target liver infection by sporozoites. Our goal is to find drugs that prevent or control liver infection. Development of such drugs will be facilitated by identification of parasite proteins required for liver infection. These proteins are potential drug targets for development of therapies that restrict Plasmodium liver infection. The aim of this Discovery award is to identify Plasmodium proteins that function in sporozoite invasion of hepatocytes and subsequent intrahepatic development.

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Document Details

Document Type
Technical Report
Publication Date
Apr 01, 2015
Accession Number
ADA621710

Entities

People

  • Purnima Bhanot

Organizations

  • Rutgers University–Newark

Tags

DTIC Thesaurus Topics

  • Biochemistry
  • Biomedical Research
  • Cells
  • Chemistry
  • Contracts
  • Epithelial Cells
  • Identification
  • Infection
  • Inhibition
  • Inhibitors
  • Molecular Genetics
  • Molecules
  • New Jersey
  • Parasites
  • Professional Development
  • Small Molecules
  • Wound Infections

Fields of Study

  • Biology
  • Chemistry
  • Medicine

Readers

  • Molecular and Cellular Biochemistry
  • Oncology
  • Parasitology and Pharmacology of Malaria.